The term q 2 represents the frequency of individuals with the disease, which in this case would be 1/50 times 1/50, or 1/2,500. In this question 2pq equals 1/25, and if it is assumed that p is close to one, q would equal 1/50 (the frequency of the mutant allele). The carrier frequency in the population for an autosomal recessive disorder is represented by 2pq, where p is the frequency of the wild-type allele (usually close to one), and q equals the frequency of the mutant allele.
This is the carrier frequency for cystic fibrosis in the northern European population.Īn alternative way to answer the question is to utilize the Hardy Weinberg equilibrium. Since both parents have to transmit the mutant allele to the child, the overall probability of the child receiving a mutant allele from each parent is 1/2,500 (1/50 x 1/50). Each parent has a one in two chance of passing the defective allele to their child, such that there is a 1/50 probability that the child will inherit a defective allele from a carrier parent (1/2 x 1/25). The probability that each parent is a carrier is 1/25. Check out this example from Kaplan Medical, and read an expert explanation of the answer. I’m sure out of all 280 questions you’ll learn something or at least reinforce a concept you’re shaky on and overall it is not a waste of time 2 level 1 deleted 2 yr.
This Step 1 study schedule is intended for strong students who score within 20 points of their target score on their initial baseline assessment. Some of the questions are shitty, but then again you can say that about the NBMES too. USMLE Step 1 Online Prep Course Kaplan Test Prep USMLE Step 1: The 6-week Study Calendar is our most intensive and aggressive timeline for Step 1.
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Kaplan Medical explains why Kaplan Medical explains whyįor an individual to express an autosomal recessive disease they would need to inherit one mutated allele from each parent, indicating that both their mother and father would be carriers for the disease. If you’re preparing for the United States Medical Licensing Examination (USMLE ) Step 2 exam, you might want to know which questions are most often missed by test-prep takers. Only practice test that’s available that’s the full 280 questions.
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